How Drugs Work

Scientists know that bacteria create their own energy, get nutrients to run their cellular processes, and multiply. But, bacteria haven't been shown to respond to external mechanical stimulation or signals in a way that's similar to how our bodies respond to touch, until now. ...more

Unfortunately, the very places we go to receive health care put us at risk for becoming infected with superbugs, bacteria exposed to so many antibiotics that they have become immune to their effects. Clostridium difficile (C. diff) is one such bacteria. It causes inflammation ...more

Got a minor cut, but no Neosporin? Rather than running to the nearest drug store, simply grab a jar of honey from your pantry and apply directly to the wound before wrapping with a band-aid. Honey is one of the world's oldest tricks in the book for dressing a skin wound and c ...more

When you have an infection, a doctor prescribes antibiotics to make the bacteria that causes it disappear. Sounds like a good idea, but the disappearance of microorganisms that have inhabited humans for millennia could be driving rising numbers of serious illness and debilitat ...more

A new study from John Rogers of the University of Illinois at Urbana-Champaign promises an exciting new tech-chic addition to the world of body modification: flexible, implantable LEDs that would radiate sub-dermal luminescence. Just imagine the possibilities. Rogers' study a ...more

Some types of bacterial infections are notoriously tough to treat — and it's not all due to antibiotic resistance. The bacteria themselves are rugged and hard to penetrate with drugs. New research may have solved that problem. A group of researchers from the University of Ill ...more

While no longer native to the United States, hospitalization from malaria occurs in this country more than most would believe. Why is that, and what can you do to protect yourself when you travel abroad to regions where malaria is active? Today, we associate malaria with trop ...more

The problem with HIV is that it attacks and kills the very cells of the immune system that are supposed to protect us from infections — white blood cells. But a new technique, developed by scientists at The Scripps Research Institute (TSRI) in La Jolla, California, offers a di ...more

More than one in ten people in the US have type 2 diabetes — that's over 29 million people. It's characterized by excessive sugar (glucose) in the blood due to the development of resistance to insulin, the hormone that normally metabolizes glucose. Deposits of folded and clum ...more

New weapons are needed to combat antibiotic-resistant bacteria. Instead of drugs, scientists have discovered in an animal study that they may be able to harness vampire bacteria to vanquish pneumonia. Microbes, good and bad, predate and outnumber us. Humans will never "win" a ...more

This week's review roundup is a diverse lot. They really only have two things in common—their indie origins and puzzle elements. Otherwise, they come from France, Spain and the U.S., a few from unknown designers and one by the guy who inspired Minecraft. Gauge French indie d ...more

For as long as I've loved SCRABBLE, I can't believe I've never come across this before. "CRAZIEST" - A short story by Liz Dubelman about words and numbers as a religion (think Pi), about SCRABBLE being the oracle, about her quest for the "triple-triple". This spoke words to m ...more

One thousand feet under the ground, extremophile microbes that have not seen the light of day for four million years are giving up some fascinating facts to scientists who go the distance. Geomicrobiologists are scientists interested in life at the crossroads of geology and m ...more

More bad news for patients who have undergone heart surgery in the past five years. A new study suggests about one-third of heater-cooler units used in cardiac procedures remain contaminated with a slow-growing, potentially fatal bacteria. Heart failure is the leading cause o ...more

Antibiotics used to prevent diseases in livestock are creating a world of hurt for humans and the soil we depend on for food. Bacterial resistance to antibiotics is a global health issue. The overuse, underuse, and poor use of these life-saving drugs is rapidly removing them a ...more

For about a million Americans each year, a joint replacement brings relief from pain and restored mobility. But, 5–10% of those people have to endure another surgery within seven years, and most of those are due to an infection in their new joint. If doctors could treat infect ...more

The Drug Enforcement Agency (DEA) has been purchasing spyware from the Milan-based Hacking Team and its US subsidiary Cicom USA since 2012. Public records reveal invoices between Cicom USA and the DEA that have ranged between $22,000 to $575,000 from 2012 to 2015. Hacking Tea ...more

Indianapolis-based motor junkie Paul Stender and his team of vehicle modders called the Indy Boys Inc have created the ultimate anti-fuel economy: a school bus outfitted with a Phantom fighter jet engine, which clocks 367 mph and burns 150 gallons of fuel in just a quarter mil ...more

As if being pregnant did not come with enough worry, a new study found that certain antibiotics are linked to an increased risk of spontaneous abortion, or miscarriage — a terrifying finding for any expectant mother. The study, published in the Canadian Medical Association Jo ...more

Young girls, especially those who live in areas where HIV is epidemic, like sub-Saharan Africa, are particularly vulnerable to becoming infected with HIV. A vaginal ring containing the antiviral agent dapivirine has been shown to decrease the chance of developing HIV-1 in adul ...more

Here at WonderHowTo, we are often presented with morally questionable HowTo's. When it comes to stocking our library, we have to weigh in the community value of indexing tutorials with potentially negative repercussions. Where is the line when it comes to areas like weapons, s ...more

For once there is good news — surprising news, but good news — in the fight against antibiotic-resistant organisms. A recent study found that Staphylococcus aureus bacteria is becoming more sensitive to some key drugs used to treat it. Helio S. Sader, Senior Director at JMI L ...more

The search is on to find antibiotics that will work against superbugs — bacteria that are rapidly becoming resistant to many drugs in our antibiotic arsenal. By carefully choosing antibiotics that killed bacteria in different ways, a team of researchers found that combination ...more

Blowing dust and fungal spores are creating a public health problem that could be just a slice of what's to come with climate change. Spurring regional expansion of ticks, and mosquitoes, warming temperatures are also rising ocean temperatures that stir up atmospheric turbule ...more

We can add one more health effect of our gut bacteria to the growing list. Researchers from the UK have just reported that the gut microbiota plays a role, both directly and indirectly, on the toxicity and efficacy of chemotherapy. Their findings are published online in the j ...more

A new medical development is going to change the way many of us look at getting the flu vaccine. A painless flu vaccine skin patch is making needles and vials a thing of the past. Researchers from the Georgia Institute of Technology and Emory University have shown that a flu v ...more

In the ongoing search to find better ways to use antibiotics, an extract made from maple syrup has some surprisingly important medical benefits. As bacteria continue to outmaneuver antibiotics, our options for treating infections narrow. Plus, slimy bacterial communities call ...more

Add breathing in your house as another possible danger to your health. If your home is sick, it's possible you could get sick too. The term "sick building syndrome" hit the airwaves years ago as a one size fits all reference to homes and buildings that are just too efficient ...more

As researchers from Yale searched our environment for compounds to aid in the battle against drug-resistant bacteria, they got an unlikely assist from ticks. Ticks are best known for being the nasty bloodsuckers that spread dangerous infections like Lyme disease, the Powassan ...more

A vaccine against HIV might prevent the disease that we can't seem to cure. Some HIV patients make antibodies that can take down the virus, much the way a vaccine might. But, scientists haven't been able to provoke that type of response in other people. However, in a process t ...more

The growing list of dangerous antibiotic resistant organisms has just acquired three new members. Researchers have discovered three new species of Klebsiella bacteria, all of which can cause life-threatening infections and have genes that make them resistant to commonly used a ...more

Peach trees and other related plants are susceptible to the devastation caused by fire blight, a contagious bacterial disease. Once contracted, infected trees have to be burned to contain the disease and prevent spread to nearby trees. Increasing resistance to antibiotic treat ...more

The search for a cancer treatment that selectively finds and kills only the cancerous cells has just made a giant leap forward. A new study published in Nature Communications, by a group of researchers from the August Pi i Sunyer Biomedical Research Institute, Barcelona Insti ...more

We fight cancer in a variety of ways, but no matter whether drugs, biologics, or our immune cells are part of the battle, they can do a better job fighting back cancer if we can help them find the tumors. Scientists from the University of Rochester Medical Center (URMC) have ...more

We don't generally think of medicine as being very relevant to Steampunk, but it was a big part of Victorian science fiction. Notable examples that you may be familiar with would be Frankenstein and The Strange Case of Dr. Jekyll and Mr. Hyde. However, in an era in which the ...more

Though it's unlikely you'll ever have a need for hostage survival skills, it never hurts to take in a few tips on what to do in the event of being accosted by Somali pirates off the Horn of Africa. Wired has tracked down a HowTo guide that addresses such a scenario. Though mos ...more

Specialized cells in the lining of the gut may provide a key to preventing an infectious brain disease caused by misfolded proteins. Don't Miss: Syphilis: An Old Disease Returns with a New Drug Resistance We can easily imagine white blood cells attacking foreign germs in th ...more

Could your fever, body aches, cough, and sore throat be the flu? Soon, finding out may not involve a trip to the doctor. Right now, diagnosing the flu is something done at your doctor's office or hospital and involves a gag-inducing brushing inside your nose to collect cells ...more

For the first time, the US Food and Drug Administration (FDA) has approved medication to treat children with a serious infection called Chagas disease, which stealthily infects and damages the hearts of millions of victims a year. Chagas disease is caused by the parasite Tryp ...more

A new study just out reveals that HIV takes hold in the human body with the help of cells that usually work to heal, not kill. HIV invades the body through genital or rectal mucous membranes. Exactly how that occurs on a molecular level was not understood until now. The study ...more

Marketing and healthcare, two of the leading industries in the adoption of augmented reality, continue to demonstrate applications for the technology in their businesses. Meanwhile, improvements to augmented reality devices are just around the corner with new developments from ...more

Usually, the mucus lining of the female genital tract presents a barrier that helps prevent infections. But, somehow, the bacteria that causes gonorrhea gets around and through that barrier to invade the female genital tract. Scientist Liang-Chun Wang, from the Department of ...more

There's only a few week left until costumes and candy take over the streets, which means they'll be more and more seven-letter words in the Scrabble Bingo of the Days that relate to the Fall season, horror movies, and of course… Halloween. Below you'll find bingo words relevan ...more

Six people have died from fungal infections in Pittsburgh hospitals since 2014—that fact is indisputable. The rest of the situation is much vaguer. A lawsuit has been filed against the hospitals on behalf of some of the deceased patients, alleging that moldy hospital linens ar ...more

A rose by any other name may smell as sweet, but one annoying invasive weed may hold the answer to treating the superbug MRSA. Researchers from Emory University have found that the red berries of the Brazilian peppertree contain a compound that turns off a gene vital to the dr ...more

The presence of certain bacteria can indicate whether the vaginal tract is healthy or not. It could also impact the likelihood of acquiring certain sexually transmitted diseases, like HIV, a new study suggests. Lactobacillus is the type of bacteria found most commonly and mos ...more

Smartphones and TVs aside, most of the electronics industry is focused on making everything smaller. From cars to cameras to computers to memory, we want power and convenience to go hand-in-hand. Professor John Rogers at the University of Illinois is ready for the next wave of ...more

Microbial cells can improve the functionality of clothes in creative and useful ways, including cooling us down during a workout or making clothing glow for better visibility. The innovative products were developed by a team of 14 researchers from MIT, in such broadly diverse ...more

Do you know how you are perceived by your peers? In real life and online? In the physical world, you could be seen as intelligent, thoughtful and hard-working, but on the Web you could be looked at as irrational, selfish and slothful. There's just something about the Internet ...more

As our cells age, they eventually mature and die. As they die, they alert nearby cells to grow and multiply to replace them. Using a special imaging process that combines video and microscopy, scientists have observed the cellular communication between dying and neighboring ce ...more

Even though HIV rates declined 18% between 2008 and 2014, 1.1 million people in the US are living with the infection. Part of that is because HIV is treatable, but not curable. HIV attacks the very cells of the immune system that should kill off the infection, and our bodies ...more